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目的观察奥美拉唑、阿莫西林联合养胃舒治疗胃溃疡的临床效果及安全性。方法选择2013年2月—2015年2月收治的60例胃溃疡患者作为研究对象,随机分为对照组和观察组各30例。对照组采取奥美拉唑(20mg/次,1次/d)+阿莫西林(500 mg/次,3次/d)治疗;观察组在对照组基础上联合养胃舒治疗,1.2g/次,2次/d;两组均治疗4周。比较两组临床疗效、Hp根除及不良反应发生情况、症状积分变化情况。计量资料组间比较采用t检验,组内比较采用配对t检验,等级资料采用秩和检验,P<0.05为差异有统计学意义。结果观察组临床治愈16例,显效6例,有效7例,无效1例;对照组临床治愈8例,显效10例,有效5例,无效7例;两组临床疗效比较差异有统计学意义(P<0.05)。观察组Hp根除率为83.3%,与对照组的56.7%比较差异有统计学意义(P<0.05)。观察组与对照组治疗后胃溃疡症状积分分别为(27.5±3.4)、(50.1±4.2)分,均较治疗前的(87.2±6.3)、(87.5±6.0)分明显下降,差异均有统计学意义(均P<0.05)。且观察组治疗后胃溃疡症状积分明显低于对照组,差异有统计学意义(P<0.05)。结论奥美拉唑、阿莫西林联合养胃舒能明显改善胃溃疡症状,Hp根除率较高,疗效明确且不良反应少,值得临床推广应用。
Objective To observe the clinical effects and safety of omeprazole and amoxicillin combined with Yangwei Shu in the treatment of gastric ulcer. Methods Sixty patients with gastric ulcer admitted from February 2013 to February 2015 were randomly divided into control group and observation group of 30 cases. The patients in the control group were treated with omeprazole (20mg / time, once daily) and amoxicillin (500mg / time, 3 times / d) Times, 2 times / d; both groups were treated for 4 weeks. Clinical efficacy, Hp eradication and adverse reactions were compared between the two groups, and the symptom scores were changed. The t test was used to compare the measurement data, the paired t test was used to compare the data of the measurement group, and rank sum test was used to classify the data. P <0.05 was considered statistically significant. Results In the observation group, 16 cases were clinically cured, 6 cases were markedly effective, 7 cases were effective and 1 case was ineffective. In the control group, 8 cases were cured, 10 cases were markedly effective, 5 cases were effective and 7 cases were ineffective. There was significant difference between the two groups P <0.05). The eradication rate of Hp in the observation group was 83.3%, which was significantly different from that of the control group (56.7%) (P <0.05). The symptom scores of gastric ulcer in observation group and control group were (27.5 ± 3.4) and (50.1 ± 4.2) points respectively, which were significantly lower than those before treatment (87.2 ± 6.3) and (87.5 ± 6.0) points, respectively Significance (both P <0.05). And symptom scores of gastric ulcer in observation group were significantly lower than those in control group, the difference was statistically significant (P <0.05). Conclusion omeprazole and amoxicillin combined with Yang Wei Shu can significantly improve the symptoms of gastric ulcer, Hp eradication rate is higher, clear effect and less adverse reactions, it is worthy of clinical application.