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急性播散性脑脊髓炎(Acute Disseminated Encephalo myelitis,ADEM)是一种急性炎症性脱髓鞘疾病。迄今为止,其病因及发病机制尚不清楚,普遍认为与感染、预防接种等因素有关。近年来,预防接种后发生的ADEM备受关注,ADEM与接种部分疫苗有时间上的关联性,但两者因果关系尚无定论。该文通过检索近些年来国内外发表的有关文献,对ADEM的基本情况及预防接种与ADEM的因果关系研究进展进行综述。
Acute Disseminated Encephalomyelitis (ADEM) is an acute inflammatory demyelinating disease. So far, its etiology and pathogenesis is not yet clear, generally believed that with infection, vaccination and other factors. In recent years, there has been much concern about the occurrence of ADEM after vaccination. There is a time-dependent relationship between ADEM and vaccination of some vaccines, but the causal relationship between the two is inconclusive. This article reviews the basic situation of ADEM and the progress in the causal relationship between vaccination and ADEM by searching the relevant literature published in recent years.