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为了了解类风湿因子 (RF)自身免疫抗体的分型 (IgG、IgM、IgA)与丙型肝炎之间的关系 ,探讨其出现的规律及与肝功能损坏情况的相关性。采用定量双抗原夹心ELISA法进行检测。结果发现抗 HCV阴性、ALT <4 0U的C组RF总阳性率为 5 % ;抗 HCV阳性、ALT <4 0U的A组为 5 6 % :抗 HCV阳性 ,ALT≥ 4 0U的B组为 89% ,C组与A、B组之间有显著性的差异P <0 .0 1)。A组lgM RF阳性率为 4 % ;B组为 5 6 % ;A组与B组之间有显著性差异 (P <0 .0 5 )。因此抗 HCV阳性者血清中各型RF总阳性率比正常对照的C组有明显的增高 ;B组的IgM RF比A组明显地增高。研究结果提示 :IgM RF的增高与丙肝患者肝功能损坏的发生与否存在密切的关系
In order to understand the relationship between the type of autoimmune antibodies (IgG, IgM, IgA) and hepatitis C in rheumatoid factor (RF), the regularity of their occurrence and the relationship with the damage of liver function were explored. Quantitative double antigen sandwich ELISA method for detection. The results showed that anti-HCV-negative, ALT <40U RF positive rate of C group was 5%; anti-HCV positive, ALT <40U of A group was 56%: anti-HCV positive, ALT 40U group B 89 %, There was a significant difference between group C and group A, B (P <0.01). The positive rate of lgM RF in group A was 4%; in group B it was 56%; there was a significant difference between group A and group B (P <0.05). Therefore, the anti-HCV positive serum RF in the total positive rate of each group than the normal control group C was significantly increased; B group IgM RF significantly higher than the A group. The results suggest that there is a close relationship between the elevated IgM RF and the occurrence of liver damage in patients with hepatitis C