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流行性出血热之严重出血,是本病重要死亡原因之一。出血热DIC 时出血的原因与机理过去尚未搞清,50年代丘氏等认为主要是毛细血管损伤、血小板减少所致。60年代赵氏等认为血小板有巨型变、成熟障碍,李氏等认为出血原因由毛细血管中毒损害,血小板减少凝血因子缺损,抗凝物质增加所致。近年来许多作者通过对本病患者从弥散性血管内凝血(DIC)方面进行临床观察与实验室检查,认为本病出血原因及出血机理与DIC有密切关系。
Severe bleeding of hemorrhagic fever is one of the important causes of death of this disease. The causes and mechanisms of hemorrhagic fever with DIC have not been clarified in the past. In the 1950s, Chu et al. Thought mainly capillary damage and thrombocytopenia. In the 1960s, Zhao et al. Thought that platelets had giant changes and maturation disorders. Li et al. Thought that the causes of bleeding were damaged by capillary poisoning, thrombocytopenic coagulation factor deficiency and the increase of anticoagulant substances. In recent years, many authors through the clinical observation of patients with disseminated intravascular coagulation (DIC) and laboratory tests, that the bleeding causes of this disease and bleeding mechanism and DIC are closely related.