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目的:观察多次使用川芎嗪(Ligustrazine,L)注射液对丙泊酚(Propofol,P)逆行性遗忘作用的影响。方法:将60只昆明种小鼠随机分成5组(n=12):川芎嗪L15组(15 mg.kg-1)、丙泊酚P5组(5 mg.kg-1)、丙泊酚P10组(10 mg.kg-1)、P5+L15组、P10+L15组。用避暗实验观察24 h后各组小鼠步入潜伏期和错误次数。结果:用药后24 h,各组间错误次数差异无统计学意义(P>0.05);与L15组相比,P10组、P5+L15组、P10+L15的潜伏期缩短(P<0.01);与P5组相比,P10组、P5+L15组、P10+L15组的潜伏期缩短(P<0.01或P<0.05)。结论:多次使用川芎嗪可增强丙泊酚的逆行性遗忘作用。
OBJECTIVE: To observe the effect of multiple injections of Ligustrazine on the retrograde amnesia of propofol (P). Methods: Sixty Kunming mice were randomly divided into 5 groups (n = 12): ligustrazine L15 group (15 mg.kg-1), propofol P5 group (5 mg.kg-1), propofol P10 Group (10 mg.kg-1), P5 + L15 group, P10 + L15 group. The mice in each group were observed for latency and number of errors after 24 hours with dark-avoidance experiment. Results: Compared with L15 group, the latency of P10 + L15 group and P10 + L15 group shortened (P <0.01) at 24 h after treatment, and there was no significant difference between the two groups (P> 0.05) P5 group, P5 + L15 group, P10 + L15 group, the incubation period was shorter (P <0.01 or P <0.05). Conclusion: Repeated use of ligustrazine can enhance the retrograde amnesia of propofol.