对孕妇高血压的降压治疗的传统目标在于预防高血压所致肾脏和脑部后遗症。最近的动物实验证明,在轻度高血压的急性期,子宫血流量减少。这一事实对胎儿有重要意义,被认为与妊娠期高血压所致胎儿出生前后的死亡率和发病率增高有关。因此选择降压药时,应同时考虑母体和胎儿的危险性。用药物降低动脉压虽可保护母体的脑血管,但亦可使子宫血流量更为减少,从而进一步危害胎儿的环境。肼苯哒嗪是妊娠期高血压短期治疗的首选药物,它可降低周围血管阻力。此外,肼苯哒嗪对心脏尚有正性肌力和变时性作用,可导致心输出量增加。对妊娠绵羊的研究证明,心输出量增多可使子宫血流量显 The traditional goal of antihypertensive treatment of high blood pressure in pregnant women is to prevent kidney and brain sequelae caused by hypertension. Recent animal experiments show that in the acute phase of mild hypertension, uterine blood flow decreased. This fact is of great importance to the fetus and is believed to be linked to an increase in the morbidity and mortality of prenatal and postnatal pregnancies caused by gestational hypertension. Therefore, the choice of antihypertensive drugs, should also consider the risk of maternal and fetal. Although drugs to reduce arterial pressure can protect the mother’s brain blood vessels, but also make the uterine blood flow is more reduced, thus further jeopardizing the fetus’s environment. Hydralazine is the first choice of short-term treatment of hypertensive disorders during pregnancy, it can reduce peripheral vascular resistance. In addition, hydralazine still has positive inotropic and chronotropic effects on the heart, which can lead to an increase in cardiac output. Studies on pregnant sheep have shown that increased cardiac output can make uterine blood flow significantly