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用普通料加胆固醇(0.5g/kg·d)喂饲新西兰兔15周,塑造高胆固醉血症模型,结果表明:胆固醇组血胆固醇明显升高,主动脉 cAMP 水平显著降低。加喂大蒜素(20mg/kg·d)可防止高胆固醇血症的发生,并能使主动脉 cAMP 水平维持正常,为大蒜素防治动脉粥样硬化提供实验依据。
Feeding New Zealand rabbits with cholesterol and cholesterol (0.5g/kg·d) for 15 weeks using a standard material to create a model of hypercholesterolrinemia. The results showed that blood cholesterol in the cholesterol group increased significantly and cAMP levels in the aorta significantly decreased. Adding allicin (20mg/kg·d) can prevent the occurrence of hypercholesterolemia and maintain normal aortic cAMP levels, providing an experimental basis for allicin to prevent atherosclerosis.