已知是红细胞唾液糖蛋白的血型糖蛋白A、B、C相当于恶性疟原虫裂殖子入侵人体红细胞时的受体。Posvol等曾提出入侵过程的两步模型:其中原虫首先结合到分子糖基化区域内的低聚糖上,而被认为位于红细胞膜附近的血型糖蛋白A的无糖区域的Wr~b抗原是入侵时的另一个受体。这是由于仅仅观察到一例缺乏Wr~b抗原,但有其它正常唾液糖蛋白的人(M.Fr.),能强烈抗感染,而 It is known that the glycophorin A, B and C of erythrocyte salivary glycoprotein are equivalent to the receptors of P. falciparum merozoites invade human red blood cells. Posvol et al. Proposed a two-step model of invasion process in which protozoa first bind to oligosaccharides within the glycosylation region of the molecule whereas the Wr-b antigen that is believed to be located in the sugarless region of glycophorin A near the erythrocyte membrane is Another receptor at invasion. This is due to the mere observation that only one human who is deficient in the Wr-b antigen but has other normal salivary glycoprotein (M.Fr.) is strongly resistant to infection and