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目的探讨孕早期胎盘生长因子(PLGF)、唐氏筛查指标在子痫前期(PE)筛查中的应用价值。方法抽取廊坊市人民医院2014年2月-2016年2月确诊的PE(分为轻度PE组、重度PE组)患者100例、正常妊娠孕妇(对照组)100例,分别通过时间分辨荧光法、荧光免疫分析法测定孕早期血清PLGF及唐氏筛查指标。结果轻度PE组、重度PE组与对照组孕妇血清PLGF、妊娠相关蛋白A(PAPP-A)、分娩孕周、新生儿出生体质量方面比较差异均有统计学意义(均P<0.05),而血清绒毛膜促性腺激素β亚单位(β-hCG)水平比较差异无统计学意义(P>0.05);血清PLGF、PAPP-A、PLGF+PAPP-A对PE筛查预测ROC曲线下面积(AUCROC)值分别为0.743、0.657、0.770;PLGF、PAPP-A、PLGE+PAPP-P对重度PE筛查敏感度分别为82.25%、82.25%、85.00%,特异度分别为79.30%、50.68%、86.05%。结论孕早期PLGF、PAPP-A对PE筛查有一定的价值,两者联合检测的敏感度、特异度更高,β-hCG对PE无预测价值。
Objective To investigate the value of placental growth factor (PLGF) and Down’s screening in pregnancy screening of preeclampsia (PE). Methods 100 patients with PE (divided into mild PE group and severe PE group) and 100 normal pregnant women (control group) were selected from the People’s Hospital of Langfang City from February 2014 to February 2016. The patients were divided into two groups according to time-resolved fluorescence Fluorescence immunoassay was used to determine serum PLGF and Down’s screening index in early pregnancy. Results There were significant differences in the serum levels of PLGF, PAPP-A, birth gestational age and newborn birth weight among mild PE group, severe PE group and control group (all P <0.05) (P> 0.05). Serum levels of PLGF, PAPP-A and PLGF + PAPP-PE in predicting the area under the ROC curve (P <0.05) AUCROC) were 0.743,0.657,0.770 respectively; the sensitivity of PLGF, PAPP-A and PLGE + PAPP-P in screening severe PE were 82.25%, 82.25%, 85.00%, and specificity were 79.30%, 50.68% 86.05%. Conclusions PLGF and PAPP-A in early pregnancy have certain value in screening of PE. The combined detection of PLGF and PAPP-A has higher sensitivity and specificity, and β-hCG has no predictive value for PE.