淋巴细胞通过血液不断出入淋巴和非淋巴器官。因此,一般来说血中淋巴细胞亚群的测定可以反映淋巴系统的情况。近年来,通过对不同疾病患者血中一套淋巴细胞亚群参数的测定,发现很多疾病会引起参数的变化。但除疾病外,许多因素(包括紧张、吸烟、服药、运动及衰老等)也能影响血中的淋巴细胞,不同因素引起的变化很容易掩盖有诊断价值的改变,如:T 淋巴细胞的数量随取样时间不同所产生的波动可达100%。因此要得到可重复的结果是很困难的,这也清楚地指明取样的高度标准化、染色及评价技术的必要性。但是,问题在于外周血淋巴细胞是否能完全反映整个淋巴系统的内部状况(见表)。血中淋巴细胞并非一定反映其他器官的病理变化 Lymphocytes constantly flow in and out of lymphatic and non-lymphoid organs through the bloodstream. Therefore, in general, the measurement of lymphocyte subsets in the blood can reflect the condition of the lymphatic system. In recent years, through the determination of a set of lymphocyte subsets in blood of patients with different diseases, many diseases have been found to cause changes in parameters. However, besides the disease, many factors (including stress, smoking, medication, exercise and aging, etc.) can also affect the blood lymphocytes. The changes caused by different factors can easily cover the diagnostic value of the changes, such as: the number of T lymphocytes Fluctuations can vary up to 100% with different sampling times. Therefore, it is difficult to obtain repeatable results, which clearly indicates the need for highly standardized sampling, dyeing and evaluation techniques. However, the question is whether peripheral blood lymphocytes can fully reflect the internal condition of the entire lymphatic system (see table). Blood lymphocytes do not necessarily reflect the pathological changes in other organs