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目的:研究血清瘦素(Lp)及可溶性瘦素受体(sLR)水平与冠心病的关系。方法:应用放射免疫分析法(RIA)及酶联免疫吸附分析法(ELISA)检测34例冠心病患者及其36例对照者血清Lp、sLR、空腹血糖(FBG)、TC、TG、HDL、LDL、胰岛素(INS)、稳态模型(HOMA)评估胰岛素抵抗(IR)(HOMA-IR)、体质指数(BMI)、腰围、臀围、腰臀比(WHR)等临床指标,分析Lp、sLR与血脂、IR及冠心病的关系。结果:冠心病组Lp、INS及HOMA-IR水平明显高于对照组,sLR水平明显低于对照组(P<0.01)。Lp与BMI、腰围、臀围、INS、HOMA-IR、TC、TG呈正相关,与sLR呈负相关;sLR与Lp、BMI、腰围、臀围呈负相关(P<0.05或P<0.01)。结论:Lp及sLR异常与肥胖、血脂异常、IR密切相关,共同参与冠心病的发生发展。
Objective: To study the relationship between serum leptin (Lp) and soluble leptin receptor (sLR) and coronary heart disease. Methods: Serum Lp, sLR, fasting blood glucose (FBG), TC, TG, HDL and LDL levels in 34 patients with CHD and 36 controls were detected by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) INS, HOMA, HOMA-IR, BMI, waist circumference, hip circumference and WHR were measured to assess the relationship between Lp, sLR and Serum lipids, IR and coronary heart disease. Results: The levels of Lp, INS and HOMA-IR in CHD group were significantly higher than those in control group, and the levels of sLR in CHD group were significantly lower than those in control group (P <0.01). Lp was positively correlated with BMI, waist circumference, hip circumference, INS, HOMA-IR, TC and TG, but negatively correlated with sLR; sLR was negatively correlated with Lp, BMI, waist circumference and hip circumference (P <0.05 or P <0.01). Conclusion: The abnormalities of Lp and sLR are closely related to obesity, dyslipidemia and IR, and participate in the occurrence and development of coronary heart disease.