天然自身抗体由胚系基因编码 ,具有IgG、IgM、IgA 3种同种型 ,其自身反应模式形成于个体发生的早期 ,并终生保持不变。天然自身抗体以Ⅴ区介导的结合性形成独特型抗独特型网络 ,构成了免疫系统的基本组成部分 ,参与免疫自稳态的调节 ,具有非特异性防御、抗炎、肿瘤监视、协助抗原递呈等多种功能。静脉输注免疫球蛋白对多种自身免疫性疾病和炎症性疾病具有良好疗效。 Natural autoantibodies are encoded by the germline genes, with three isoforms of IgG, IgM, and IgA. Their autoantibodies form in the early stages of an individual’s life and remain unchanged throughout life. Natural autoantibodies form unique anti-idiotypic networks mediated by β-region binding and constitute an essential part of the immune system and are involved in the regulation of immune homeostasis with nonspecific defenses, anti-inflammatory, oncological surveillance, and assistance in antigen delivery Was waiting for a variety of functions. Intravenous immunoglobulin has good efficacy against a variety of autoimmune and inflammatory diseases.