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目的：探讨脑室外引流术后并发颅内感染的影响因素。方法对105例经额脑室前角穿刺脑室外引流术患者的临床资料进行回顾性分析。结果在排除年龄、性别、手术耗时等干扰因素的情况下：（1）置管时间＞10 d者颅内感染率最高（16．0％），其次是≥7 d者（12．5％），＜7 d者最低（10．0％）。（2）单侧外引流颅内感染率低于双侧外引流（10．5％/16．7％）。（3）引流管在原切口的颅内感染率最高（23．1％），距原切口3 cm-5 cm的感染率最低（9．5％）。（4）未预防性应用抗生素的感染率最高（10．7％），术后3d鞘内注射感染率最低（4．5％）。结论脑室外引流术后并发颅内感染受影响因素众多，对患者进行全面的观察和治疗，可有效避免或减少颅内感染的发生。“,”Objective To explore the influencing factors of intracranial infection after external ventricular drainage (EVD) .Methods Clinical data of 105 patients undergoing external ventricular drainage via fron-tal ventricle anterior horn puncture were retrospectively analyzed .Results Excluding interference factors such as age ,gender ,operation time :(1) intracranial infection rates of patients with intubation time >10 days were the highest (16 .0% ) ,second ≥ 7 (12 .5% ) ,third < 7 (10 .0% ) .(2) intracranial infection rate of unilateral was lower than that of bilateral external ventricular drainage (10 .5% /16 .7% ) .(3) intracra-nial infection rate of drainage tube in the primary incision was the highest (23 .1% ) and was the lowest in 3 cm-5 cm site from the primary incision (9 .5% ) .(4) intracranial infection rate was the highest in pa-tients without prophylactic application of antibiotics (10 .7% ) and was the lowest in ones undergoing in-trathecal injection of antibiotics within 3 days after operation (4 .5% ) .Conclusion Influencing factors of intracranial infection after EVD are numerous ,comprehensive observation and treatment for patients could effectively avoid or reduce the development of intracranial infection .