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1937年Albright等人报告了抗V-D性佝偻病。该病系基因缺陷所致,缺陷位于X染色体短臂部分,应称为“伴性遗传低磷酸盐佝偻病”。特征为生长缓慢、佝偻病骨骼畸形、肾性磷酸盐丢失和低磷血症,血钙、V-D代谢物及甲状旁腺素正常。作者观察了33例患者的X线动态变化。报告2例女性患儿,分别为16岁和15岁,由于胫骨近侧部分骨骺过早闭合,加重了身材矮小和下肢弯曲。作者认为这两个病例身材矮小、腿弯曲畸形系骨骺板部分
1937 Albright et al reported anti-V-D rickets. The disease is caused by genetic defects, defects located in the short arm of the X chromosome, should be referred to as “associated with genetic hypophosphatemic rickets.” Characterized by slow growth, rickets, skeletal deformities, renal phosphate loss and hypophosphatemia, serum calcium, V-D metabolites and normal parathyroid hormone. The authors observed the X-ray dynamic changes in 33 patients. Two women were reported to be 16 and 15 years old, respectively, with premature closure of the proximal part of the tibia and increased short stature and lower limb flexion. The authors believe that these two cases of short stature, leg bending deformity Department of epiphyseal plate