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目的研究长托宁及阿托品在治疗急性有机磷中毒中的效果。方法将144例急性有机磷中毒患者分成治疗组和对照组,各72例。治疗组使用长托宁、对照组使用阿托品,同时均伍用氯解磷定注射液,对两组治疗效果进行分析。结果治疗组患者胆碱酯酶活力复原时间、中毒症状缓解消失时间、不良反应发生率、用药次数、住院时间明显小于对照组(P<0.05);两组患者治愈率差异无统计学意义(P>0.05)。结论长托宁与阿托品治疗急性有机磷中毒患者均有较好疗效,但长托宁用药次数少,患者恢复快,不良反应发生率低。
Objective To study the effects of penehyclidine hydrochloride and atropine in the treatment of acute organophosphate poisoning. Methods 144 patients with acute organophosphate poisoning were divided into treatment group and control group, 72 cases in each. The treatment group used penehyclidine, while the control group used atropine, both with chlorpheniramine given injection, the treatment effect of the two groups were analyzed. Results The recovery time of cholinesterase, the disappearance of poisoning symptoms, the incidence of adverse reactions, frequency of medication and hospital stay in the treatment group were significantly less than those in the control group (P <0.05). There was no significant difference in the cure rate between the two groups (P > 0.05). Conclusions Long-acting and atropine are effective in treating patients with acute organophosphate poisoning. However, they are less frequently used, patients recover faster and the rate of adverse reactions is lower.