目的探讨新生儿胃肠穿孔的诊断和治疗方法。方法 32例胃肠穿孔新生儿经X线、彩超及腹腔穿刺等明确诊断,胃肠穿孔一经确诊后均采取手术治疗。结果治愈17例,死亡15例,治愈率53.13%。死亡病例与早产低体质量儿,延期诊断,误诊,合并感染、休克、多脏器损害等因素有关。结论早期诊断、重视术前处理、合理选择术式、术后常规应用全静脉营养支持、加强术后呼吸循环管理等综合治疗是提高疗效的关键。 Objective To investigate the diagnosis and treatment of gastrointestinal perforation in neonates. Methods 32 cases of gastrointestinal perforation of newborns by X ray, color Doppler ultrasound and abdominal puncture and other clear diagnosis, gastrointestinal perforation were diagnosed after surgery. Results 17 cases were cured, 15 died, the cure rate was 53.13%. Mortality and preterm low birth weight children, deferred diagnosis, misdiagnosis, co-infection, shock, multiple organ damage and other factors. Conclusions Early diagnosis, emphasis on preoperative treatment, rational choice of surgical procedures, regular application of total parenteral nutrition support and postoperative respiratory cycle management are the keys to improve the curative effect.