采用口服化学预防剂防止尾蚴侵入,预防血吸虫病的效力未曾探讨过。作者先用吡喹酮作为这种预防药进行实验,发现其在阻断尾蚴侵袭方面具有中等效力,但这种作用需依赖于药物的载体。本实验选用4～6周龄ICR小鼠,分为3大组。实验组小鼠先通过胃管饲喂法分别给予溶解于0.3ml不同载体的吡喹酮,药物总量为200mg/kg,分4次给药,50mg/kg/2小时,8小时内完成;而载体对 The use of oral chemopreventive agents to prevent cercariae invasion, prevention of schistosomiasis efficacy has not been explored. The authors first tested praziquantel as a prophylactic drug and found that it had intermediate potency in blocking cercariae invasion, but this effect depended on the drug carrier. The experiment selected 4 to 6 weeks old ICR mice, divided into 3 groups. The mice in the experimental group were administered with praziquantel dissolved in 0.3 ml of different carriers respectively by gastric tube feeding method, the total amount of the drugs was 200 mg / kg, administered in 4 doses, 50 mg / kg / 2 hours and completed in 8 hours; The vector pair