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B7RP-1(B7 related protein 1)是B7家族的新成员,可持续表达于B淋巴细胞表面。它与其特异性受体ICOS(Inducible costimulator)的结合在机体再次体液免疫应答过程中T细胞的增殖、活化、Th2型细胞因子分泌以及B细胞的增殖、分化、抗体分泌等方面发挥了重要的调节作用。B7RP-1/ICOS信号途径在机体抗感染、抗肿瘤、抗移植排斥等细胞免疫应答过程中也发挥了重要的作用。
B7RP-1 (B7 related protein 1) is a new member of the B7 family that is expressed on the surface of B lymphocytes. Its binding to its specific receptor ICOS (Inducible costimulator) plays an important regulatory role in the proliferation and activation of T cells, the secretion of Th2-type cytokines and the proliferation, differentiation and antibody secretion of T cells in the body’s humoral immune response effect. The B7RP-1 / ICOS signaling pathway also plays an important role in the cellular immune response such as anti-infective, anti-tumor and anti-transplant rejection.