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目的总结和分析奥美拉唑为主的四联疗法治疗80例消化性溃疡的疗效。方法将2009年2月至2011年1月收治的80例消化性溃疡患者随机分为对照和治疗两组,对照组40例,服用雷尼替丁、阿莫西林、呋喃唑酮和枸橼酸铋钾,治疗组40例,服用奥美拉唑、阿莫西林、呋喃唑酮和枸橼酸铋钾,共治疗4周,比较两组治愈率。结果对照组治愈率为50%,治疗组的治愈率为75%,对照组治愈率低于治疗组(P<0.05);对照组总有效率为90%,治疗组的总有效率为97.5%,对照组与治疗组的总有效率比较无统计学意义(P>0.05);对照组Hp根除率75%,治疗组Hp根除率90%,对照组根除率低于治疗组(P<0.05)两组比较差异有统计学意义(P<0.05)。结论奥美拉唑为主的四联疗法在促进溃疡愈合、快速改善临床症状、Hp根除率方面优于雷尼替丁为主的四联疗法,奥美拉唑为主的四联疗法以有效率高、复发率低被临床广泛推广应用。
Objective To summarize and analyze the therapeutic effect of omeprazole-based quadruple therapy on 80 cases of peptic ulcer. Methods Eighty patients with peptic ulcer who were admitted from February 2009 to January 2011 were randomly divided into control and treatment groups, 40 patients in the control group were treated with ranitidine, amoxicillin, furazolidone and bismuth potassium citrate , The treatment group 40 cases, taking omeprazole, amoxicillin, furazolidone and bismuth potassium citrate for a total of 4 weeks, the cure rate was compared between the two groups. Results The cure rate of the control group was 50%, the cure rate of the treatment group was 75%, the cure rate of the control group was lower than that of the treatment group (P <0.05); the total effective rate of the control group was 90% and the total effective rate of the treatment group was 97.5% (P> 0.05). In the control group, the eradication rate of Hp was 75%, the eradication rate of Hp in the treatment group was 90%, and the eradication rate in the control group was lower than that in the treatment group (P <0.05) The difference between the two groups was statistically significant (P <0.05). Conclusions Omeprazole-based quadruple therapy is superior to ranitidine-based quadruple therapy in promoting ulcer healing, rapidly improving clinical symptoms and Hp eradication rates, and omeprazole-based quadruple therapies include High efficiency, low recurrence rate is widely used in clinical practice.