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目的探讨滑膜肉瘤组织中p27和cyclin D1的表达及预后意义。方法采用免疫组化方法检测60例滑膜肉瘤中p27和cyclin D1的表达情况,分析其与临床病理资料及患者术后生存时间的关系。结果 p27和cyclin D1在滑膜肉瘤中的阳性率分别为45%(27/60)和40%(24/60)。p27阳性与滑膜肉瘤的组织学分级及肿瘤转移相关(P<0.05);cyclin D1阳性与肿瘤转移相关(P<0.05)。p27阳性组术后生存情况明显优于阴性组(P<0.05)。结论p27和cyclin D1的异常表达与滑膜肉瘤的发生、发展密切相关,且p27低表达可能提示预后不良。
Objective To investigate the expression and prognostic significance of p27 and cyclin D1 in synovial sarcoma. Methods Immunohistochemistry was used to detect the expression of p27 and cyclin D1 in 60 cases of synovial sarcoma. The relationship between p27 and cyclin D1 was analyzed with clinicopathological data and postoperative survival time. Results The positive rates of p27 and cyclin D1 in synovial sarcoma were 45% (27/60) and 40% (24/60), respectively. The positive rate of p27 was correlated with the histological grade of synovial sarcoma and tumor metastasis (P <0.05). The positive rate of cyclin D1 correlated with tumor metastasis (P <0.05). The postoperative survival in p27 positive group was significantly better than that in negative group (P <0.05). Conclusion The abnormal expression of p27 and cyclin D1 is closely related to the occurrence and development of synovial sarcoma, and the low expression of p27 may indicate the poor prognosis.