论文部分内容阅读
目的观察急性心肌梗死(AMI)患者接受静脉溶栓治疗血清蛋白-肌钙蛋白I(cTnI)的变化及其评价溶栓后冠脉再通的价值。方法 66例AMI者均接受静脉溶栓治疗,应用ELISA法测定cTnI值。结果溶栓再通组52例,溶栓未通组14例,两组的cTnI释放大部分存在双峰,溶栓再通组第一峰时(11.34±3.2)h、第二峰时(23.80±12.42)h,比未通组相对应的时间明显提前(P<0.05),cTnI第一峰时比CK-MB峰时提前。以cTnI第一峰值到达时间≤14h判定溶栓再通的敏感性、特异性及准确性分别为92.31%、64.29%及66.5%。结论在大多数AMI患者血清cTnI释放呈双峰,其第一、二峰值到达时间在溶栓再通组前移,血清cTnI≤14h作为评价溶栓再通与否,有一定的判定价值。
Objective To investigate the changes of serum cTnI in patients with acute myocardial infarction (AMI) undergoing intravenous thrombolysis and to evaluate the value of coronary recanalization after thrombolysis. Methods Sixty-six patients with AMI underwent intravenous thrombolysis. The cTnI level was measured by ELISA. Results Thrombolytic recanalization group (n = 52) and thrombolysis failed group (n = 14). Most of the cTnI released in both groups had bimodal peak, the first peak of thrombolysis recanalization group (11.34 ± 3.2) h and the second peak ± 12.42) h, which was significantly earlier than that of the untreated group (P <0.05). The first peak of cTnI was earlier than the peak of CK-MB. The sensitivity, specificity and accuracy of determining the recanalization of thrombolysis with cTnI first peak arrival time ≤14h were 92.31%, 64.29% and 66.5% respectively. Conclusions The peak of cTnI release in patients with AMI is bimodal. The arrival times of the first and second peak in the thrombolytic reperfusion group move forward. Serum cTnI≤14h is of great value in the evaluation of recanalization of thrombolytic therapy.