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过去十五年中,随着造血干细胞实验研究的迅速发展,体外培养方法逐渐广泛地应用于临床观察与研究。因而,对血液系统疾患的许多方面有了进一步的了解和新的概念。一、急性粒细胞性白血病(AML) 1 白血病细胞特性: 表现在生长型,分化能力,对调控因子的反应,细胞周期以及漂浮密度等方面。70年代初期有过较多的报道。首先注意到白血病GM—CFu。(L—GM—CFu。)的分化与集落形成并非自发性的,它们的增生需要CSF(Greenberg 1971,Moore 1973,Metcalf 1974)。白血病细胞具有较低的漂浮密度(50—60%低于1.060克/立方厘米)与较低比值的DNA
In the past fifteen years, with the rapid development of experimental research on hematopoietic stem cells, in vitro culture methods are widely used in clinical observation and research. Thus, there are many aspects of the blood system disorders have been further understanding and new concepts. First, acute myelogenous leukemia (AML) 1 leukemia cell characteristics: performance in growth, differentiation, response to regulatory factors, cell cycle and floating density and so on. There have been more reports in the early 1970s. The first note of leukemia GM-CFu. (L-GM-CFu.) Differentiation and colony formation are not spontaneous, and their proliferation requires CSF (Greenberg 1971, Moore 1973, Metcalf 1974). Leukemic cells have a lower floating density (50-60% less than 1.060 g / cm) and a lower ratio of DNA