青霉素过敏及过敏性休克反应在临床工作中时常发生,但一家多例对青霉素过敏在国内未见报道。笔者遇见一家三代共11口人,其中9人均对青霉素过敏,现报告如下。先证者,女,48岁。因受凉后畏寒、发热、咳嗽,于1982年3月10日来门诊治疗。查体:体温38.2℃,脉搏84次/分,呼吸22次/分,血压13.3/9.3kPa。急性病容,神志清楚,双肺闻及散在喘鸣音,心脏无杂音,肝脾未扪及。实验室检查,白细胞15100/mm~3,中性分叶核粒细胞69%,杆状核粒细胞2%,淋巴细胞29%。Hb11.5g/dl。胸部透 Penicillin allergy and anaphylactic shock reactions occur frequently in clinical work, but more than one case of penicillin allergy in the country has not been reported. The author met a total of 11 generations of three generations, of which 9 were allergic to penicillin, are as follows. Proof, female, 48 years old. Chill due to cold, fever, cough, in March 10, 1982 outpatient treatment. Physical examination: body temperature 38.2 ℃, pulse 84 beats / min, breathing 22 beats / min, blood pressure 13.3 / 9.3kPa. Acute illness, conscious, lung smear and scattered in the wheeze, heart no noise, no palpable liver and spleen. Laboratory tests, white blood cells 15100 / mm ~ 3, 69% of neutral leaf nuclear granulocytes, 2% of rod-like nucleated cells, lymphocytes 29%. Hb 11.5 g / dl. Chest through