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目的 探讨百色市慢性乙肝患者重叠感染TTV状况及其基因型特点。方法 采用PCR法检测TTVDNA ,微板核酸杂交 -ELISA法检测TTV基因型。结果 本地慢性乙肝患者TTVDNA总感染率 13 2 9% ,与健康体检者比较差异有显著性 (P <0 0 5 ) ,慢性轻度乙肝感染率 6 5 2 % ,慢性中度乙肝感染率 15 2 8% ,慢性重度乙肝感染率 17 5 0 % ,三者比较差异无显著性 (P >0 0 5 ) ;2 1例TTVDNA阳性患者中Ⅰ型 15例 ,占 71 4 3% ,Ⅱ型 2例 ,占 9 5 2 % ,Ⅰ /Ⅱ混合型 4例 ,占 19 0 5 %。结论本地慢性乙肝患者重叠感染TTV较常见 ,其TTV基因型可分为Ⅰ型、Ⅱ型、Ⅰ /Ⅱ混合型 ,以Ⅰ型为主 ,TTV重叠感染可能不导致慢性乙型肝炎病人病情的加重。
Objective To investigate the status of TTV infection and its genotypes in patients with chronic hepatitis B in Baise city. Methods TTVDNA was detected by PCR method and TTV genotype by ELISA. Results The total TTV DNA infection rate in local chronic hepatitis B patients was 13.29%, which was significantly different from that of healthy subjects (P <0.05), chronic mild hepatitis B infection rate was 65.2%, and chronic moderate hepatitis B infection rate was 15 2 8%, and chronic severe hepatitis B infection rate was 175.0%, there was no significant difference among the three groups (P> 0.05). Among the 21 TTVDNA positive patients, 15 cases were type Ⅰ (71.4%), 2 cases , Accounting for 95.2%, 4 cases of Ⅰ / Ⅱ mixed type, accounting for 19 0 5%. Conclusions TTV infection in patients with chronic hepatitis B is more common in China. TTV genotypes can be divided into type Ⅰ, type Ⅱ and type Ⅰ / Ⅱ, and type I predominance. TTV overlap infection may not lead to the exacerbation of chronic hepatitis B .