从1918年采用第一个抗血吸虫药物-吐酒石以来,为了发展理想的抗血吸虫药物,试验了30万个化合物。理想的抗血吸虫药需具备下列特性:(1) 对人体无副作用和毒性;(2) 对人体的3种主要血吸虫都很有效;(3)口服一次或治疗一天即有较好的效果;(4) 对人体内的各期血吸虫都有作用。对血吸虫病化疗状况的评论性回顾(Is-lip、Friedheim、Davis、Hoffmann)指出仍须有用于大规模化疗的新药。在下面将集中介绍两种市售的化合物,即敌百虫和羟氨喹,以及一些新的有意义的实验药物。 Since 1918, the first anti-schistosome drug - spit tartar, since the development of the ideal anti-schistosome drugs, tested 300,000 compounds. The ideal anti-schistosomiasis requires the following properties: (1) no side effects and toxicity to the human body; (2) effective against all three major human schistosomes; (3) effective once-daily or one-day treatment; 4) on the human body have various stages of schistosome effect. A commentary review of the status of chemotherapy for schistosomiasis (Is-lip, Friedheim, Davis, Hoffmann) points out the need for new drugs for large-scale chemotherapy. In the following, two commercially available compounds, trichlorfon and hydroxyquramine, as well as some new and interesting experimental drugs will be introduced.