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1984年,Quesada等报道:用干扰素治疗7例HCL病人取得良好的效果。他们用的干扰素非纯品,其中一些病人无全血细胞减少,有些则是来自各医疗中心而未曾治疗者。该报告很少做免疫学方面的探讨。伦敦大学医院与Burroughs Wellco- me公司合作于1984年元月开始在美国进行干扰素试验,以检测高纯度α干扰素(Wellferon)对全血细胞减少性毛细胞白血病是否有效,并用免疫表面标记法跟踪其药物效应。对象和方法受试者14人(男11,女3),年龄32～71岁(平均50岁)均为典型HCL,其中11人曾做过脾切除术。3例未做过脾切除,其中2人
In 1984, Quesada et al reported that interferon treatment of 7 patients with HCL achieved good results. They used non-pure interferon, some of whom had no pancytopenia, while others were from various centers without treatment. The report seldom deals with immunology. The University of London Hospital in collaboration with Burroughs Wellcoment Inc. started an interferon trial in the United States in January 1984 to test the effectiveness of high-purity Wellferon on pancytopenic hairy cell leukemia and to follow up with immunosurveillance Its drug effect. Subjects and methods Subjects 14 (male 11, female 3), aged 32 to 71 years (mean 50 years) were typical HCL, of whom 11 had splenectomy. 3 cases had not been splenectomy, 2 of them