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目的探讨心力衰竭患者血浆中可溶性Fas(sFas)水平与心功能分级及心衰心室重构的关系。方法测定65例心力衰竭患者血浆sFas/sFas配体(sFasL)水平,分析sFas与心功能间的相关性。结果 sFas水平与心功能严重程度相一致,心功能越差,血浆sFas水平越高,高血浆sFas水平是心力衰竭患者的独立危险因素。结论 sFas的检测水平与心衰心功能分级呈明显正相关性,检测Fas/FasL系统的表达水平可间接作为心力衰竭心室重构的分析指标。
Objective To investigate the relationship between plasma soluble Fas (sFas) level and heart function classification and heart failure and ventricular remodeling in patients with heart failure. Methods The plasma level of sFas / sFas ligand (sFasL) was measured in 65 patients with heart failure. The correlation between sFas and cardiac function was analyzed. Results The level of sFas was consistent with the severity of cardiac function. The worse the cardiac function, the higher the level of sFas in plasma and the high plasma level of sFas were independent risk factors in patients with heart failure. Conclusion The detection level of sFas is positively correlated with the grade of heart failure. Detecting the expression level of Fas / FasL system can indirectly serve as an index for the analysis of ventricular remodeling in heart failure.