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6-巯基嘌呤 (6 - MP)是急性淋巴细胞白血病 (AL L )缓解后化疗中最有效的药物之一 [1 ] ,作为治疗 AL L 的抗嘌呤代谢药物 ,6 - MP本身是无内在生物活性的 ,只有经过一系列代谢生成硫鸟嘌呤核苷酸 (6 - Thioguanine nucleotides,TGNs)后才具有抗肿瘤活性 [2 ] 。Christie等 [3
6-Mercaptopurine (6-MP) is one of the most effective chemotherapeutic agents for the treatment of acute lymphoblastic leukemia (AL L) [1]. 6-MP is an endogenous organism as an anti-purine metabolite for the treatment of AL L Active, only after a series of metabolism to generate thioguanine nucleotides (6 - Thioguanine nucleotides, TGNs) before antitumor activity [2]. Christie et al [3