Three-component Ocean Bottom Seismometers, portable land stations and marine air gun seismic sources were used to carry out an onshore-offshore deep seismic profile in northeastern South China Sea. This profile, orientated in NNW-SSE, was as long as 500 km and perpendicular to the strike of regional tectonics. The offshore data were processed in Taiwan Ocean University using a number of available software and the onshore data were analyzed in South China Sea Institute of Oceanology by new-written programs and public software. Preliminary results show that the seismic data are in good quality and contain rich information of deep structure. Seismic phases, e.g. Pg, PmP and Pn, are identified in the offset range 5～220 km, which will provide an important dataset for the deep crustal structure and oil-gas basin evolution studies of this region.