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目的探讨老年单纯收缩期高血压患者微量白蛋白尿(MAU)与心血管风险的相关性。方法选择老年单纯收缩期高血压患者187例,采用免疫比浊法测定尿微量白蛋白含量。根据MAU检测结果分为MAU阴性组76例和MAU阳性组111例。结果随着收缩压及脉压的增高,MAU阳性的危险性显著增加,MAU阳性患者数也呈显著性增加;收缩压以及脉压与尿白蛋白(24h)排泄量均呈显著正相关(均P<0.05)。MAU阳性组总体靶器官损害、左心室肥厚、心肌梗死、外周血管疾病、糖尿病以及肾功能不全发生率显著高于MAU阴性组;在控制年龄、收缩压、脉压、总胆固醇、高密度脂蛋白的情况下,MAU阳性与左心室肥厚、外周血管疾病呈独立相关(均P<0.05)。结论MAU阳性是老年单纯收缩期高血压心血管风险的独立危险因素。
Objective To investigate the correlation between microalbuminuria (MAU) and cardiovascular risk in elderly patients with isolated systolic hypertension. Methods 187 elderly patients with isolated systolic hypertension were enrolled in this study. Urine microalbuminuria was measured by immunoturbidimetry. MAU test results were divided into MAU negative group of 76 cases and MAU positive group of 111 cases. Results With the increase of systolic blood pressure and pulse pressure, the positive risk of MAU increased significantly and the number of MAU positive patients also increased significantly. Systolic blood pressure and pulse pressure were positively correlated with urinary albumin (24h) excretion P <0.05). The overall incidence of target organ damage, left ventricular hypertrophy, myocardial infarction, peripheral vascular disease, diabetes mellitus and renal insufficiency in the MAU positive group was significantly higher than that in the MAU negative group. There was no significant difference in age, systolic blood pressure, pulse pressure, total cholesterol, high density lipoprotein MAU positive was independently associated with left ventricular hypertrophy and peripheral vascular disease (all P <0.05). Conclusion MAU positive is an independent risk factor for cardiovascular risk of isolated systolic hypertension in the elderly.