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目的探讨红霉素、白细胞介素-2联合顺铂胸腔注入治疗恶性胸腔积液的疗效、临床症状缓解时间及胸水消失的时间。方法按随机原则分为红霉素治疗组,胸腔内注入5%葡萄糖注射液20mg+红霉素0.5mg+顺铂40mg,每周1次;IL-2组胸腔内注入5%葡萄糖注射液20g+IL-2106U+顺铂40mg每周1次。结果治疗后两组患者胸水消失时间及临床症状缓解率无明显差异,但IL-2组,胸水消失的平均时间较红霉素组胸水消失平均时间少1.5d。结论用红霉素、IL-2联合顺铂治疗恶性胸腔积液疗效确定,在胸水消失的时间及临床症状缓解上,IL-2组优于红霉素组。
Objective To investigate the efficacy of erythromycin, interleukin-2 combined with cisplatin in the treatment of malignant pleural effusion, the clinical symptom relief time and the disappearance of pleural effusion. Methods According to the principle of randomness, the patients were divided into erythromycin group, intrapleural injection of 5% dextrose injection 20mg + erythromycin 0.5mg + cisplatin 40mg once a week, intrapleural injection of 5% glucose 20g + IL -2106U + cisplatin 40mg once a week. Results After treatment, there was no significant difference between the two groups in the time of disappearance of pleural effusion and clinical symptom relief. However, the average time of disappearance of pleural effusion in IL-2 group was 1.5 days less than that of erythromycin group. Conclusion The efficacy of erythromycin, IL-2 and cisplatin in the treatment of malignant pleural effusions has been confirmed. IL-2 is better than erythromycin in the time of disappearance of pleural effusion and clinical symptom relief.