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目的:测定尼美舒利在兔体内药物代谢动力学过程,比较片剂、混悬剂、栓剂的药动学参数。方法:用高效液相色谱法测定血浆中尼美舒利浓度,用3P87程序处理血药浓度数据。结果:片剂与混悬剂的药动学参数无显著性差异(P>0.05),栓剂的T_(max)、t1/2ke明显长于片剂和混悬剂,相对于片剂的生物利用度为79.9％,相对于混悬剂的生物利用度为74.5％。
OBJECTIVE: To determine the pharmacokinetics of nimesulide in rabbits and to compare the pharmacokinetic parameters of tablets, suspensions and suppositories. Methods: The concentration of nimesulide in plasma was determined by HPLC, and the plasma concentration data were processed by 3P87 program. Results: The pharmacokinetic parameters of tablets and suspensions showed no significant difference (P> 0.05). The T max and t1 / 2ke of suppositories were significantly longer than those of tablets and suspensions. The relative bioavailability 79.9%, and the bioavailability relative to the suspension is 74.5%.