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在急性心肌梗塞(AMI)的酶学诊断中,以往一致公认肌酸激酶 MB(CK-MB)和乳酸脱氢酶1(LDH_1)具有高度特异性。最近一些研究报告指出,除 AMI 以外的其它某些疾病(如横纹肌瘤或其它肿瘤、糖尿病等)和长期紧张运动(如长跑)的健康人亦有 MB 升高;甚至某些药物(阿斯匹林、茶碱等)中毒也可造成 MB 上升。因此,使得人们对 MB 诊断 AMI 的价值产生了怀疑。特别是近年来血栓溶解剂,如链激酶、尿激酶、组织型纤溶酶
In the enzymology diagnosis of acute myocardial infarction (AMI), creatine kinase MB (CK-MB) and lactate dehydrogenase 1 (LDH-1) have conventionally been recognized to be highly specific. Some recent studies have reported MB elevated in certain diseases other than AMI (such as rhabdomyosarcoma or other tumors, diabetes, etc.) and healthy people with long-term intense exercise (such as long-distance running); even certain drugs Lin, theophylline, etc.) poisoning can also cause MB to rise. Therefore, people are suspected of the value of MB in diagnosing AMI. In particular, thrombolytic agents in recent years, such as streptokinase, urokinase, tissue-type plasmin