将 30只小鼠均分为 5组 ,实验组分别吸入甲苯二异氰酸酯 ( TDI)每立方米 4.30± 0 .60 mg 1～ 4周 ,采用免疫组织化学方法检测内皮素 - 1 ( ET- 1 )在肺内的表达。结果 :实验组小鼠肺内炎症细胞增多 ,以巨噬细胞和淋巴细胞为主。吸入 TDI 1～ 4周后 ,气道上皮ET- 1表达渐减少 ,血管平滑肌细胞 ET- 1表达渐增多。提示 :TDI可引起小鼠肺内炎症细胞出游 ,降低气道上皮 ET- 1的表达 ,增加血管平滑肌细胞 ET- 1的表达 Thirty mice were equally divided into 5 groups. In the experimental group, TDI was 4.30 ± 0.60 mg per square meter for 1 ~ 4 weeks respectively. Endothelin-1 (ET-1) was detected by immunohistochemical method. Expression in the lungs. Results: The number of inflammatory cells in the lung increased in the experimental group, mainly in macrophages and lymphocytes. After 1 to 4 weeks of TDI inhalation, the expression of ET-1 in airway epithelium gradually decreased and the expression of ET-1 in vascular smooth muscle cells gradually increased. Tip: TDI can cause inflammatory cells in the lungs of mice travel, reduce the expression of ET-1 in the airway epithelium and increase the expression of ET-1 in vascular smooth muscle cells