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在辽宁开原县黄旗寨乡进行了地方性汀病遗传度调查。群体发病率为2.39％。作者调查了134名先证者的系谱,包括237个家庭,在1002名一级亲属中有77名病人(发病率为7.68％)。根据Falconer氏的公式(1965)计算出本病的遗传度为45.7±5.7％(黄旗寨乡)。本文还分析了克汀病人婚配类型和他们子女患病的关系。作者认为为克汀病具有明显的遗传因素以及本病给社会和家庭造成沉重的负担,因此认为应及早制定出对病人治疗和预防新生儿患病的措施,以降低本病的发病率。
In the county of Kaiyuan County, Liaoning Huangqi Zhai conducted a survey of endemic tingi hereditary degree. The incidence of the group was 2.39%. The authors investigated the pedigree of 134 probands, including 237 families, and 77 of 1002 first-degree relatives (incidence 7.68%). According to Falconer’s formula (1965), the heritability of the disease was calculated as 45.7 ± 5.7% (Huangqi Village). The article also analyzes the relationship between the type of marriage and the prevalence of their children. The authors believe that for cretinism has obvious genetic factors and the disease to the community and the family caused a heavy burden, so that should be developed as soon as possible for the treatment of patients and prevention of neonatal illness measures to reduce the incidence of this disease.