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用1段合成的108bpDNA及免疫PCR法,研究了SLE血清抗双链DNA抗体识别的DNA序列。结果发现:10个长度为108bp序列各异的已知DNA片段,同具有亿万变化的108bpDNA片段库一样,与抗双链DNA抗体有良好反应,其中间25个bp的变异不影响抗体与抗原反应;SLE血清中抗体趋向于与易形成非bata-DNA结构的DNA特异结合
The DNA sequence recognized by anti-double-stranded DNA antibody of SLE serum was studied by using 108bp DNA synthesized in one step and immunoprecipitation method. The results showed that 10 known DNA fragments of 108bp in length had the same reactivity with anti-dsDNA antibody as those of billions of 108bp DNA fragments, and the 25 bp bp mutation did not affect the antibody and antigen Reaction; antibodies in SLE serum tend to specifically bind to DNA that readily forms non-bata-DNA structures