论文部分内容阅读
目的探讨胃癌组织中KAI1/CD82的表达及其与肿瘤转移的关系。方法采用组织芯片技术及免疫组化方法检测223例胃癌组织的KAI1/CD82的蛋白表达,分析其与临床病理特征的关系。结果胃癌组织中KAI1/CD82的阳性表达率为53.8%。其表达与患者的性别、年龄、胃癌分期无关,而与肿瘤的分化程度、浸润深度、淋巴结转移密切相关。二元Logistic回归前进法显示,分化程度是影响KAI1/CD82表达最显著的因素。结论 KAI1/CD82表达可作为评估胃癌预后的指标。
Objective To investigate the expression of KAI1 / CD82 in gastric carcinoma and its relationship with tumor metastasis. Methods Tissue microarray technique and immunohistochemistry were used to detect the protein expression of KAI1 / CD82 in 223 cases of gastric cancer and their relationship with clinicopathological features was analyzed. Results The positive rate of KAI1 / CD82 in gastric cancer was 53.8%. Its expression was not related to the patient’s gender, age, stage of gastric cancer, but closely related to the degree of tumor differentiation, depth of invasion and lymph node metastasis. Binary logistic regression analysis showed that the degree of differentiation was the most significant factor affecting KAI1 / CD82 expression. Conclusion KAI1 / CD82 expression can be used as an index to evaluate the prognosis of gastric cancer.