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目的观察阿托伐他汀对伴颈动脉粥样硬化斑块的短暂性脑缺血发作(TIA)患者的影响。方法采用随机、对照的方法进行研究,将88例伴颈动脉粥样硬化斑块的TIA患者分为两组,阿托伐他汀治疗组(44例)在常规内科治疗基础上加用阿托伐他汀20mg/d,对照组(44例)采用常规治疗。结果阿托伐他汀治疗组治疗6个月后较对照组颈动脉中层厚度(CA-IMT)、斑块检出率和斑块数目均下降。结论阿托伐他汀能减轻颈动脉粥样硬化的程度,有稳定斑块作用,但未显示对TIA复发或进展有预防作用。
Objective To investigate the effect of atorvastatin on patients with transient ischemic attack (TIA) with carotid atherosclerosis plaque. Methods A randomized, controlled study was conducted to divide 88 TIA patients with carotid atherosclerotic plaques into two groups. Atorvastatin group (44 cases) was treated with atorvastatin Statin 20mg / d, control group (44 cases) using conventional therapy. Results Atorvastatin treatment group 6 months after treatment than the control group carotid artery middle thickness (CA-IMT), plaque detection rate and plaque number decreased. Conclusions Atorvastatin can reduce the degree of carotid atherosclerosis and stabilize the plaque. However, atorvastatin does not show a preventive effect on the recurrence or progression of TIA.