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目的了解登革热疫点健康人群感染状况,为预防及控制登革热提供依据。方法在江门市江海区礼乐街道2014年曾发生登革热疫情的4个疫点随机抽取245名身体健康、2周内无发热史且无登革热病史的本地居民,采集血清标本并用酶联免疫法检测血清中抗登革病毒IgG抗体,与非疫点健康人群的血清标本进行对比。在疫点开展问卷调查,调查登革热感染因素,并进行非条件Logistic回归分析。结果登革热疫点健康人群抗登革病毒IgG抗体阳性率24.49%(60/245),非疫点抗体阳性率3.09%(13/421),两者差异具有统计学意义(X~2=72.69,P<0.001)。抗体阳性率随着年龄的上升而下降(趋势检验X~2=7.07,P<0.05)。经过单因素和多因素非条件Logistic回归分析,影响登革热IgG抗体阳性率的因素有:蚊帐的使用,水生植物的种养和家中环境。结论登革热暴发疫点健康人群感染比例较高,需要针对高危因素预防和控制登革热的流行。
Objective To understand the infection status of dengue fever in healthy population and provide basis for prevention and control of dengue fever. Methods Forty-five local residents were randomly selected from 4 epidemic areas where the dengue outbreak occurred in Li Le Street in Jianghai District in Jiangmen City in 2014. There were no fever history within 2 weeks and no history of dengue fever. Serum samples were collected and detected by enzyme-linked immunosorbent assay Serum anti-dengue virus IgG antibodies were compared with serum samples from non-infected healthy subjects. A questionnaire survey was conducted at the epidemic site to investigate the factors affecting dengue infection and to conduct non-conditional logistic regression analysis. Results The positive rate of anti-dengue virus IgG was 24.49% (60/245) in healthy population and 3.09% (13/421) in non-dengue point antibody in dengue epidemic point population. The difference was statistically significant (X 2 = 72.69, P <0.001). Antibody positive rate decreased with age (trend test X ~ 2 = 7.07, P <0.05). After univariate and multivariate non-conditional logistic regression analysis, the factors affecting the positive rate of dengue IgG antibody were: the use of mosquito nets, aquatic plant breeding and home environment. Conclusion The infection rate of dengue outbreak in healthy population is high, so it is necessary to prevent and control the epidemic of dengue for the risk factors.