蛋白激酶CK2是一种真核细胞中普遍存在的信使非依赖性丝 /苏氨酸蛋白激酶 ,其主要功能是作为参与细胞信号转导的一种重要分子 ,通过对底物的磷酸化而在细胞增殖和分化、信号的转导和加工、细胞凋亡等方面起重要作用。针对CK2的抑制剂的研究也取得了很大进展 ,CK2的抑制剂在探讨CK2的作用机制及在治疗某些类型的肿瘤和促进细胞凋亡方面越来越引起人们的关注。本文就蛋白激酶CK2的抑制剂的研究及应用作一综述 Protein kinase CK2, a ubiquitous messenger-independent silk / threonine protein kinase in eukaryotic cells, functions primarily as an important molecule involved in cell signaling through the phosphorylation of substrates Cell proliferation and differentiation, signal transduction and processing, apoptosis and other aspects play an important role. Much progress has been made in the research of inhibitors of CK2. Inhibitors of CK2 have drawn more and more attention in exploring the mechanism of action of CK2 and in treating certain types of tumors and promoting apoptosis. This review summarizes the research and application of inhibitors of protein kinase CK2