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目的探讨辛伐他汀治疗老年高脂血症的使用剂量及临床疗效。方法将118例老年高脂血症患者分为大剂量组和小剂量组,各59例,分别给予20mg辛伐他汀和10mg辛伐他汀治疗,观察两组患者治疗疗效。结果大剂量组治疗显效率和总有效率为69.49%和98.31%,均明显高于小剂量组的54.24%和84.75%(P<0.05);两组患者治疗期间药物不良反应发生率分别为8.47%和6.78%,组间比较无统计学意义(P>0.05)。结论大剂量(20mg)辛伐他汀治疗老年高脂血症可提高治疗疗效,且安全性较好,值得临床借鉴采用。
Objective To investigate the dose and clinical efficacy of simvastatin in the treatment of senile hyperlipidemia. Methods 118 cases of elderly patients with hyperlipidemia were divided into high-dose group and low-dose group, each 59 cases, respectively, given 20mg simvastatin and 10mg simvastatin treatment was observed in two groups of patients. Results The effective rate and total effective rate of high dose group were 69.49% and 98.31%, which were significantly higher than those of low dose group (54.24% vs 84.75%, P <0.05). The incidences of adverse drug reactions in the two groups were 8.47 % And 6.78% respectively. There was no significant difference between the two groups (P> 0.05). Conclusion High-dose (20mg) simvastatin treatment of senile hyperlipidemia can improve the curative effect, and it is safe and worthy of clinical reference.