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用ＬＳＡＢ免疫组化法测定２００例大肠癌组织中ｎｍ２３－Ｈ１基因蛋白，结果发现：（１）ｎｍ２３－Ｈ１在２００例大肠癌中阳性表达率２８．５％，其中在乳头状腺癌，高分化腺癌，粘膜内癌及无淋巴结转移者阳性率显著高于其它各型（Ｐ＜０．０１）。（２）ｎｍ２３－Ｈ１阳性病例比阴性病例有较高的生存率和较低的复发率（Ｐ＜０．０１）。结果表明ｎｍ２３－Ｈ１在大肠癌中的阳性表达在抑制肿瘤复发及转移中起了重要作用，可作为大肠癌患者预测转移和预后的有用指标
Using LSAB immunohistochemical method to determine nm23-H1 gene protein in 200 cases of colorectal cancer tissue, the results showed that: (1) nm23-H1 positive expression rate in 200 cases of colorectal cancer 28.5%, of which in papillary adenocarcinoma, high The positive rate of differentiated adenocarcinoma, intramucosal carcinoma, and no lymph node metastasis was significantly higher than that of other types (P<0.01). (2) Compared with negative cases, nm23-H1 positive cases had higher survival rate and lower recurrence rate (P<0.01). The results indicate that the positive expression of nm23-H1 in colorectal cancer plays an important role in inhibiting tumor recurrence and metastasis, and can be used as a useful index for predicting metastasis and prognosis in patients with colorectal cancer.