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阐明ONO-1078(ONO,4-氧-8-[对-(4-苯丁氧基)苯甲酰氨基]-2-(5-四唑基)-4H-1-苯并毗喃)对神经原性刺激诱导心血管反应的作用.方法:观察豚鼠心房和心室伊文思蓝渗出以及平均主动脉压(MAP)变化.结果:在阿托品(1 mg·kg~(-1),iv)预先处理后,电刺激迷走神经(ESV,10 Hz,5 ms,2或10 V,90 s)显著增高伊文思蓝渗出;辣椒素和P物质也增加染料渗出并降低平均动脉压(MAP).ONO(0.03,0.1 mg·kg~(-1),iv)抑制ESV的反应,在刺激强度低(2 V)时更明显;ONO 0.03 mg·kg~(-1)减弱辣椒素引起的微血管渗漏和低血压,但对P物质无影响.结论:ONO-1078可能通过抑制感觉神经肽释放而调节神经原性炎症时的心血管反应.
It is demonstrated that ONO-1078 (ONO, 4-oxo-8- [p- (4-phenylbutoxy) benzamido] -2- (5-tetrazolyl) To observe the effect of neurogenic stimulation on cardiovascular responses.Methods: The changes of Evans blue exudation and mean aortic pressure (MAP) in atrial and ventricular chambers of guinea pigs were observed.Results: In atropine (1 mg · kg -1), iv) Electrical stimulation of the vagus nerve (ESV, 10 Hz, 5 ms, 2 or 10 V, 90 s) significantly increased Evans blue exudation after pretreatment; capsaicin and substance P also increased dye exudation and decreased mean arterial pressure (MAP) (0.03,0.1 mg · kg -1) iv) inhibition of ESV response was more pronounced at low stimulus (2 V); ONO 0.03 mg · kg -1 attenuated capsaicin-induced microvascular Leakage and hypotension but had no effect on substance P. CONCLUSION: ONO-1078 regulates the cardiovascular response to neurogenic inflammation by inhibiting the release of sensory neuropeptides.