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摘 要：目的 探讨雌激素对雄性大鼠和雌性大鼠局限性脑缺血的治疗作用和性别因素的影响。方法 应用局限性脑缺血动物模型。结果 实验1组实验大鼠阻断大脑中动脉（MCA）后的死亡率：正常雄鼠和雌鼠均为12．5％（2/16），去卵巢雌鼠为23．5％。冠状面的脑梗死范围（平均值±标准差）：正常雌鼠为9．5％±1．0％，正常雄鼠为16．6％±1．6％（两者相比P＜0．01），去卵巢雌鼠为16．0％±1．4％（与正常雌且相比P＜0．01）。实验2组实验大鼠在阻断MCA 40min后给去卵巢雌鼠注射雌二醇（E2）或其溶液羟丙基-β-环右旋聚糖（HPCD）。HPCD治疗组死亡率为40％（4/10），雌激素治疗组为0％。脑梗死的范围：HPCD治疗组为19．3％±1、8％，雌激素治疗组为8．0％±1．2％（两者相比 P<0．01）。血清中雌激素含量：HPCD治疗组为 14．5±1．2pg/ml，雌激素治疗组为142．7±23．6pg／ml（两者相比 P<0．01）。结论 在 MCA阻断造成局限性脑缺血时，雌激素有保护脑缺血的作用。
Abstract: Objective To investigate the therapeutic effect of estrogen on focal cerebral ischemia in male and female rats and the influence of gender factors. Methods The use of local cerebral ischemia model. Results In experimental group 1, the mortality of experimental rats after blocking middle cerebral artery (MCA) was 12.5% (2/16) in normal males and females, and 23.5% in ovariectomized females. Coronary cerebral infarct size (mean ± standard deviation) was 9.5% ± 1.0% in normal females and 16.6% ± 1.6% in normal males (P <0. 01), ovariectomized females 16.0% ± 1.4% (P <0.01 vs. normal females). In experimental group 2, ovariectomized female rats were injected with estradiol (E2) or its solution hydroxypropyl-β-dextran (HPCD) after 40 min of blockade of MCA. The mortality rate was 40% (4/10) in the HPCD treatment group and 0% in the estrogen treatment group. The range of cerebral infarction was 19.3% ± 1, 8% in HPCD treated group and 8.0% ± 1.2% in estrogen treated group (P <0.01 for both). Serum estrogen levels: 14.5 ± 1.2 pg / ml in the HPCD-treated group and 142.7 ± 23.6 pg / ml in the estrogen-treated group (P <0.01 for both). CONCLUSIONS: Estrogen protects against cerebral ischemia when MCA blockade results in localized cerebral ischemia.