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目的：探讨SCD-1过表达对Aβ1-40诱导的巨噬细胞膜脂的影响。方法用带有SCD-1的腺病毒表达载体pcDNA3,通过腺病毒转染，使其在巨噬细胞中过表达。检测未干预组及过表达组巨噬细胞膜脂成分及细胞膜流动性的改变。结果过表达组巨噬细胞中巨噬细胞膜主要的磷脂成分降解(P<0.05)；细胞膜荧光偏振度(ρ)、微粘度(η)和分子排列有序性系数(γ)增加(P<0.05)。结论过表达SCD-1可增加Aβ1-40诱导的巨噬细胞膜的稳定性。“,”Objective To observe the effects of Stearoyl-CoA desaturease-1 (SCD-1) overexpression on Changes of membrane phospholipids in macrophages induced by β-amyloid protein (Aβ). Methods the expression vector pcDNA3 with SCD-1 adenovirus, by adenovirus transfection, and its over expression in macrophages. Flow detection untreated group and overexpression of macrophage membrane lipid composition and group cellmembrane changes. Results the expression of macrophage membrane phospholipid degradation in macrophages in the main group (P < 0.05); cellmembrane fluorescence polarization (P), micro viscosity (η) and the molecular ordering coefficient (γ) increased (P < 0.05). Conclusion SCD-1 can increase the expression of macrophage membrane stability of A β1-40.