论文部分内容阅读
目的系统评价中国人细胞毒性T淋巴细胞相关抗原4(cytotoxic T lymphocytes associated antigen-4,CTLA-4)基因第一外显子49位点A/G、启动子-318位点C/T多态性与Graves病(Graves’ disease,GD)的相关性。方法计算机检索CNKI、VIP、CBM、PubMed、EMbase以及The Cochrane Library数据库,收集国内外关于中国人群CTLA-4基因第一外显子49位点A/G、启动子-318位点C/T多态性与GD相关性的病例-对照研究。检索时限均从1980年1月至2011年12月。按纳入和排除标准筛选文献、提取资料和评价质量后,采用RevMan 5.0和STATA 12.0软件进行Meta分析。结果①中国人群CTLA-4第一外显子49位点A/G多态性的系统评价共纳入10个研究。Meta分析结果显示:具有基因型G/G的中国人群发生GD的风险高于具有基因型A/A[OR=3.38,95%CI(2.07,5.51)]和基因型A/G[OR=1.72,95%CI(1.31,2.25)]的中国人群。同时,等位基因G引起GD的发病风险高于等位基因A[OR=1.87,95%CI(1.44,2.41)]。②中国人群CTLA-4启动子-318位点C/T多态性的系统评价共纳入5个研究。Meta分析结果显示:在GD发病风险方面,具有基因型T/T的中国人群与具有基因型C/C[OR=0.75,95%CI(0.26,2.12)]和基因型C/T[OR=0.92,95%CI(0.31,2.73)]的中国人群相当。同时,等位基因T引起GD的发病风险与等位基因C相当[OR=0.83,95%CI(0.61,1.12)]。结论现有研究的Meta分析结果显示,中国人群CTLA-4基因第一外显子49位点等位基因G与GD发病有关,但尚未发现启动子-318位点等位基因及基因型与GD发病相关。由于受纳入研究的质量和数量所限,上述结论尚需更多高质量的研究加以验证。
Objective To systematically evaluate the A / G of 49 locus in promoter 1 of cytotoxic T lymphocytes associated antigen-4 (CTLA-4) gene and C / T polymorphism of promoter-318 site Sex and Graves disease (Graves’ disease, GD) correlation. Methods CNKI, VIP, CBM, PubMed, EMbase and The Cochrane Library were searched by computer. The data of A / G 49, C / T of promoter-318 locus A case-control study of the association of status with GD. Retrieval time from January 1980 to December 2011. After selecting and documenting the criteria for inclusion and exclusion, extracting data and evaluating the quality, Meta-analysis was performed using RevMan 5.0 and STATA 12.0 software. Results ① A total of 10 studies were included in the systematic reviews of A / G polymorphism at the 49 exon 49 of CTLA-4 in Chinese population. Meta-analysis showed that the risk of developing GD was higher in Chinese population with genotype G / G than in those with genotype A / A [OR = 3.38, 95% CI (2.07, 5.51)] and genotype A / G , 95% CI (1.31,2.25)] of the Chinese population. At the same time, allele G caused a higher risk of GD than allele A [OR = 1.87, 95% CI (1.44, 2.41)]. ② The Chinese population CTLA-4 promoter -318 site C / T polymorphism in the systematic evaluation of a total of five studies included. The results of Meta analysis showed that in Chinese population with genotype T / T and genotype C / C [OR = 0.75,95% CI (0.26,2.12)] and genotype C / T [OR = 0.92, 95% CI (0.31, 2.73)] in China. At the same time, allele T caused a comparable risk of GD to that of allele C [OR = 0.83, 95% CI (0.61, 1.12)]. CONCLUSIONS: Meta-analysis of the existing studies shows that allele G of 49 locus of CTLA-4 gene in Chinese population is related to the pathogenesis of GD. However, there is no association between GD-318 locus allele and genotype Disease related. Due to the quality and quantity of the included studies, the above conclusion still needs more high-quality research to be verified.