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为观察硫普罗宁（ＭＰＧ）对小鼠实验性肝损伤的保护作用。取健康小鼠１２０只，随机分为４组，即溶剂对照组，模型对照组，ＭＰＧ高剂量组和ＭＰＧ低剂量组，每组３０只。采用腹腔注射给药，实验组（包括ＣＣｌ４及ＭＰＧ大小剂量组）先给体积分数为０２５％ＣＣｌ４１０ｍｌ／ｋｇ；对照组给等量溶剂。３０ｍｉｎ后，用ＭＰＧ７５及１５０ｍｇ／（ｋｇ·ｄ）进行治疗，连用１５ｄ；对照组给溶剂１０ｍｌ／ｋｇ。各组动物在实验的３６ｈ，７ｄ及１５ｄ分批处死，测定血清中丙氨酸氨基转换酶（ＡＬＴ），天门冬氨酸氨基转换酶（ＡＳＴ），丙二醛（ＭＤＡ）及病理组织学的改变情况。结果：ＭＰＧ剂量为７５及１５０ｍｇ／（ｋｇ·ｄ），血清中ＡＬＴ，ＡＳＴ及ＭＤＡ明显降低，肝细胞变性，坏死明显减轻。提示：ＭＰＧ对由ＣＣｌ４所致的急性肝损伤有明显的治疗作用。其机理可能与清除自由基有关
To observe the protective effect of tiopronin (MPG) on experimental liver injury in mice. 120 healthy mice were randomly divided into 4 groups: solvent control group, model control group, high-dose MPG group and low-dose MPG group, 30 rats in each group. By intraperitoneal injection, the experimental group (including CCl4 and MPG size dose group) first give the volume fraction of 0 25% CCl410ml / kg; the control group to the same amount of solvent. After 30min, treatment with MPG75 and 150mg / (kg · d) for 15d; control group to the solvent 10ml / kg. The animals in each group were sacrificed at 36h, 7d and 15d after the experiment, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA) and histopathological Change the situation. Results: The doses of MPG were 75 and 150 mg / (kg · d), respectively. The serum levels of ALT, AST and MDA were significantly decreased, and the degeneration and necrosis of hepatocytes were significantly reduced. Tip: MPG has a significant therapeutic effect on acute liver injury caused by CCl4. The mechanism may be related to the removal of free radicals