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癌细胞的永生化是肿瘤细胞区别于正常细胞的重要特征之一 ,也是肿瘤生长和转移的关键。自从 1989年Ｍｏｒｉｎ[1 ]首次在人的癌细胞系中发现端粒酶以来 ,肿瘤细胞永生化的“端粒—端粒酶”假说已为越来越多的研究结果所证实。端粒酶与肿瘤的关系已经成为近年来的瘤分子生物学领
Immortalization of cancer cells is one of the important characteristics of tumor cells from normal cells, and it is also the key of tumor growth and metastasis. Since Morin [1] first discovered telomerase in human cancer cell lines in 1989, the “telomere-telomerase” hypothesis of tumor cell immortalization has been confirmed by more and more researches. The relationship between telomerase and tumor has become a leader of tumor molecular biology in recent years