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目的观察缅甸拉咱市间日疟对氯喹的敏感性。方法 54例间日疟患者镜检原虫密度≥500个原虫/μl全血,2周内未服用过抗疟药物或四环素和磺胺类等有抗疟作用的药物。患者给予氯喹25mg(含基质)/kg体重,口服,连续3d,同时伍用伯喹0.25mg(基质)/kg体重,连续14d。于服药当天、服药后第1、2、3、7、14、21和28d和6个月对患者进行观察和随访。结果 54例间日疟患者的平均退热时间为(23.46±11.40)h,原虫无性体平均转阴时间为(35.93±12.62)h。所有患者原虫无性体和配子体3d内全部转阴,1例患者疑出现氯喹一级抗性。结论缅甸拉咱市现症间日疟患者对氯喹敏感。
Aim To observe the sensitivity of Chlorpacia vivax to Plasmodium vivax in our city of Lama, Myanmar. Methods 54 patients with Plasmodium vivax had a density of ≥500 protozoa / μl whole blood, no antimalarial drugs or antimalarial drugs such as tetracycline and sulfonamide within 2 weeks. Patients were given chloroquine 25mg (containing matrix) / kg body weight, orally for 3 consecutive days, at the same time with primaquine 0.25mg (matrix) / kg body weight, continuous 14d. The patients were observed and followed at the first, second, third, seventh, fourteenth, twelfth, 28th and six months after taking the drug. Results The mean duration of fever in 54 malaria patients was (23.46 ± 11.40) h and that of protozoal asexual individuals was (35.93 ± 12.62) h. All patients with protozoan protozoa and gametocytes in the negative all over the 3d, 1 patients suspected of emergence of chloroquine resistance. Conclusions Clonidine in Japan is susceptible to chloroquine in Lazan, Myanmar.