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喹吡酮对体外培养的姜片虫有较强的作用,接触药液3.9μg/ml1′内腹吸盘即迅速松弛扩大。虫体的反应与药物剂量有关。剂量在250μg/ml以上时,虫体明显挛缩。经低浓度药物(3.9μg/ml和15.6μg/ml)作用3′或10′的虫可于30′内恢复其体态和活动,并在24、48、72小时常规培养中存活和产卵。药物浓度在62.5μg/ml以上时,虫的体表出现泡状隆起,在以后的常规培养中排卵量显著减少,24小时内全部死亡。但从培养液中收集的虫卵,于30℃恒温培育12～15天仍可孵出毛蚴。 接触吡喹酮3′或10′的姜片虫,其体壁、肠道和生殖器官均出现不同程度的退行性变化。
Quinpyrazone on the ginger cultured in vitro has a strong role in contact with drug solution 3.9μg / ml 1 ’intra-abdominal suction that is rapidly expanding relaxation. Insect response and drug dose. The dose of 250μg / ml or more, the body significantly contracture. The 3 ’or 10’ worms treated with low concentrations of drugs (3.9 μg / ml and 15.6 μg / ml) restored their status and activity within 30 ’and survived and spawned in 24, 48 and 72 hours of routine culture. When the drug concentration was above 62.5μg / ml, the body surface of the worm appeared bubbly bulge, the ovulation amount decreased significantly in the routine culture afterwards, and all died within 24 hours. However, collected from the culture solution of eggs, incubated at 30 ℃ incubated 12 to 15 days can still hatch miracidia. The zooxanthellae exposed to 3 ’or 10’ praziquantel showed varying degrees of degenerative changes in the body wall, gut and genital organs.